Suggestions regarding missing cat

My cat, Jojo, hasnt come home since Thursday, when she went out at 1 pm. Now, we have searched the immediate neighbourhood AND the outer area multiple times each day (and still do). Cats usually don't go on the main road or very busy areas. I've spotted almost every stray cat in our neighborhood but still couldn't find Jojo. I've called out her name everywhere and there is no response.

Now for context, Jojo has always been going out for time to time before her neutering. It was either because of her heat or sense of play, etc. but that was a reason for going out. Now after neutering (which was about 2-3 months ago), she showed no signs of wanting to go out by herself but did only when she got the chance (even then, not always), and would always come back few hours later.

Thursday, she went out like that. When i came home, I didn't think much of it because she always comes home. But, she still hasn't come home and cannot be spotted anywhere nearby.

Anyone got any suggestions on what I should do? Or if you've had a similar situation?