Why I take the Blueprint stack
Last year I went through an obsession and researched longevity for 8-12 hours daily for 4 months whilst working a full time job. At first I was dubious.. Spermidine? High-dose Vitamin K? Kyolic? Why on earth would anyone take all these strange supplements? Why not take something natural?
I read 3 longevity books (Attia, Sinclair and de Grey), listened avidly to Peter Attia (best longevity information out there) and Rhonda Patrick. I prefer Attia's approach to exercise and Rhonda Patrick's approach to supplements. I paid $7k to go to a longevity clinic and found a shit ton of problems, one of them being a genetic disorder which makes me certain to get Hypertrophic Cardiomyopathy when I get older. I started looking into these supplements like Spermidine, and how it might slow age-related cardiomyopathy. I read a review paper which looked into the mechanisms of how genetic mutations in the MYBPC3 gene would result in a manifestation of HCM as one ages. I don't understand this paper (planning on rereading it), but at the end it mentioned various potential treatments of slowing down disease progression like Rapamycin, PUFA (in EVOO), Spermidine, etc. I went through this same approach for all my other problems like high cholesterol, family history of type 2 diabetes, EDS (and all the problems it comes with it like exercise intolerance, low bone density verified by DEXA scan) etc. Almost every supplement I could think of was covered in Blueprint. Some important bits are missing but only because they only apply to me, like PCSK9 inhibitors and other cholesterol lowering medication to tackle Lp(a) and LDL-C, probiotics like Pendulum. Those I plan to supplement outside of blueprint. Still though, a lot of the stack is something I want to consume.
I still wasn't convinced of the safety of Blueprint, why would someone take NAD boosters when Sinclair himself mentioned higher doses resulting in cancer spreading faster? Also is there any benefit for someone in their 20s who should have high NAD?. So I tested myself and found I had extremely low NAD (<25) despite being young (I found the root cause but not going to share that). I did a lot more investigation but I don't have time to write it all out. In the end I decided to trust the Blueprint stack. Clearly someone already did the investigation I did and put everything into a stack that is easy to consume and not too expensive for someone who has a good paying job. I don't have to worry about dosage (CoAs sometimes show the actual dose is lower than the listed dose but I bet this problem impacts every supplement company), microplastics, pesticides, etc. As long as Bryan is in change and his friends/family are on the Blueprint stack, I know he will never compromise on these details that every other company overlooks. I'm still not 100% sure taking the stack is safe for me, its impossible to be sure for almost any supplement (maybe outside Magnesium, Vit D and K2). Maybe the reason there is no history of cancer in my family is because all our NAD levels are low, but then again cancer is smart enough to survive using whatever mechanisms are available to it, NAD or not. So I am not sure.. but I'd rather do something than nothing. That is why I take the Blueprint stack.