Drugs that are actively unpleasant (doctors interest)

Basically I like doing drugs because they’re weird rather than because they’re euphoric or enjoyable.

I have a very addictive personality so I prefer to do stuff that doesn’t have any potential for that

I’m looking at trying something that has actively unpleasant effects. The problem is that they seem to be generally extremely unsafe, or impossible to get ahold of.

Nitroglycerine apparently induced migraines, but it’s unattainable due to being a bomb component

Adenosine apparently causes a feeling of impending doom, but info on it seems to dubiously tiptoe around the potential lethality when administered by a non doctor (would like more info if possible)

Capsaicin seems is the only easily attainable drug in the “deliberately unfun” class ive tried. I’ve had plenty of unfun with it already though.

Are there any substances with which the “high” feels more like a hangover should? I’m asking doctors because I don’t think drug users are likely to know. Anything thats physically safe, has a, relatively short-lived (~1 hour) duration and a strong, unpleasant “high” is on the table

EDIT: lots of people suggesting salvia. It’s an excellent suggestion that I forgot to mention I have used a lot of already